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| 货号 | RC0206 |
| 说明书 | |
| CAS号 | C17H19N3O3S |
| 分子式 | 73590-58-6|
| 分子量 | 345.42 |
| 产品描述 | |
| 描述 | Omeprazole 是一种质子泵抑制剂，用于治疗消化不良。 |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | Omeprazole；奥美拉挫 |
| 可溶性/溶解性 | DMSO ：34.5 mg/mL (100 mM) |
| 1eq. HCl ：17.3 mg/mL (50 mM) | |
| 生物活性 | |
| 靶点 | Proton pump |
| In vitro(体外研究) | Omeprazole potently induces cytochrome P4501A1 mRNA expression in primary human hepatocytes, whereas this effect is not detected in mouse primary hepatocytes. Omeprazole induces transcription of reporter genes via the xenobiotic response element that is recognized by the ligand-activated dioxin receptor in human hepatoma cells. Omeprazole causes a strong inhibition of basal natural killer (NK) activity in spleen cells (SC) from untreated CD2F1 mice. Omeprazole causes a rapid, strong effect on various types of cytotoxic lymphocytes ranging from cytotoxicity inhibition to irreversible cell damage. Omeprazole induces a significant inhibition of cytotoxic activity of all types of effector cells after 30 min incubation. Omeprazole decreases the activation ofosteoclasts but increases that of osteoblasts in vitro, in part causing an osteopetrosis-like effect. |
| In vivo(体内研究) | Omeprazole blocks H(+)-K(+)-ATPase, thus enhances degeneration and macrophage-mediated elimination of parietal cells and also causes an increase in preparietal cell production. Omeprazole temporarily changes the dynamic features of parietal cells in the rabbit to make them die early and grow fast. |
| 分子结构图 | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 | |
